Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …

MU Rehman, N Sehar, NJ Dar, A Khan, A Arafah… - Neuroscience & …, 2023 - Elsevier
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Curcumin and its derivatives as theranostic agents in Alzheimer's disease: The implication of nanotechnology

U Shabbir, M Rubab, A Tyagi, DH Oh - International Journal of Molecular …, 2020 - mdpi.com
Curcumin is a polyphenolic natural compound with diverse and attractive biological
properties, which may prevent or ameliorate pathological processes underlying age-related …

Curcumin in health and diseases: Alzheimer's disease and curcumin analogues, derivatives, and hybrids

E Chainoglou, D Hadjipavlou-Litina - International journal of molecular …, 2020 - mdpi.com
Worldwide, Alzheimer's disease (AD) is the most common neurodegenerative multifactorial
disease influencing the elderly population. Nowadays, several medications, among them …

Quercetin‐3‐O‐Glucuronide Alleviates Cognitive Deficit and Toxicity in Aβ1‐42‐Induced AD‐Like Mice and SH‐SY5Y Cells

M Xu, H Huang, X Mo, Y Zhu, X Chen… - Molecular nutrition & …, 2021 - Wiley Online Library
Scope Alzheimer's disease (AD) is characterized by amyloid‐β (Aβ) related imbalance, Tau‐
hyperphosphorylation, and neuroinflammation, in which Aβ and neuroinflammation can …

[图书][B] Neurodegeneration: Diagnosis, prevention, and therapy

MK Poddar, A Chakraborty, S Banerjee - 2021 - books.google.com
Neurodegenerative disorders (NDDs) are a broad range of pathological conditions which
target the neurons, creating problems in movements and mental functions. The NDDs have …

Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system

P Hrelia, G Sita, M Ziche, E Ristori… - Oxidative Medicine …, 2020 - Wiley Online Library
Neurodegenerative disease is an umbrella term for different conditions which primarily affect
the neurons in the human brain. In the last century, significant research has been focused on …

Targeting Tau hyperphosphorylation via kinase inhibition: strategy to address Alzheimer's disease

AA Turab Naqvi, GM Hasan… - Current topics in …, 2020 - ingentaconnect.com
Microtubule-associated protein tau is involved in the tubulin binding leading to microtubule
stabilization in neuronal cells which is essential for stabilization of neuron cytoskeleton. The …

Effects of subtoxic concentrations of atrazine, cypermethrin, and vinclozolin on microRNA-mediated PI3K/Akt/mTOR signaling in SH-SY5Y cells

A Graziosi, G Sita, C Corrieri, S Angelini… - International Journal of …, 2022 - mdpi.com
Endocrine-disrupting chemicals (EDCs) are different natural and synthetic chemicals that
may interfere with several mechanisms of the endocrine system producing adverse …

Chrysophanol improves memory ability of d-galactose and Aβ25–35 treated rat correlating with inhibiting tau hyperphosphorylation and the CaM–CaMKIV signal …

T Ye, X Li, P Zhou, S Ye, H Gao, R Hua, J Ma, Y Wang… - 3 Biotech, 2020 - Springer
This study was aimed to investigate the effect of Chrysophanol (CHR) on Alzheimer's
disease. We also attempted to understand the potential mechanisms. An Alzheimer's …

Protection against amyloid-β oligomer neurotoxicity by small molecules with antioxidative properties: potential for the prevention of Alzheimer's disease dementia

W Araki, F Kametani - Antioxidants, 2022 - mdpi.com
Soluble oligomeric assemblies of amyloid β-protein (Aβ), called Aβ oligomers (AβOs), have
been recognized as primary pathogenetic factors in the molecular pathology of Alzheimer's …