Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemma

M Popovic, L Dhaenens, A Boel… - Human …, 2020 - academic.oup.com
BACKGROUND Trophectoderm (TE) biopsy and next generation sequencing (NGS) are
currently the preferred techniques for preimplantation genetic testing for aneuploidies (PGT …

The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies

E Fragouli, S Munne, D Wells - Human reproduction update, 2019 - academic.oup.com
BACKGROUND Embryos that are able to form blastocysts have succeeded in activating their
genome and differentiating into two cell types—an external layer of trophectoderm cells …

[HTML][HTML] The “mosaic” embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy

NR Treff, D Marin - Fertility and sterility, 2021 - Elsevier
Preimplantation genetic testing for aneuploidy (PGT-A) remains one of the most
controversial topics in reproductive medicine. With more than 40% of in vitro fertilization …

Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy

M Popovic, L Dhaenens, J Taelman… - Human …, 2019 - academic.oup.com
STUDY QUESTION What is the accuracy of preimplantation genetic testing for aneuploidies
(PGT-A) when considering human peri-implantation outcomes in vitro? STUDY ANSWER …

[HTML][HTML] Chromosomal, gestational, and neonatal outcomes of embryos classified as a mosaic by preimplantation genetic testing for aneuploidy

M Viotti, E Greco, JA Grifo, M Madjunkov, C Librach… - Fertility and sterility, 2023 - Elsevier
Objective To understand the clinical risks associated with the transfer of embryos classified
as a mosaic using preimplantation genetic testing for aneuploidy. Design Analysis of data …

Molecular drivers of developmental arrest in the human preimplantation embryo: a systematic review and critical analysis leading to mapping future research

K Sfakianoudis, E Maziotis, E Karantzali… - International journal of …, 2021 - mdpi.com
Developmental arrest of the preimplantation embryo is a multifactorial condition,
characterized by lack of cellular division for at least 24 hours, hindering the in vitro …

Optimized NGS approach for detection of aneuploidies and mosaicism in PGT-A and imbalances in PGT-SR

CM García-Pascual, L Navarro-Sánchez, R Navarro… - Genes, 2020 - mdpi.com
The detection of chromosomal aneuploidies and mosaicism degree in preimplantation
embryos may be essential for achieving pregnancy. The aim of this study was to determine …

Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial

K Ozgur, M Berkkanoglu, H Bulut, GDA Yoruk… - Journal of Assisted …, 2019 - Springer
Purpose This paper aims to investigate the efficacy of IVF with preimplantation genetic
testing for aneuploidy (PGT-A), using only best-scoring blastocysts from young (≤ 35 years) …

Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing …

TH Chuang, JY Hsieh, MJ Lee, HH Lai… - MHR: Basic science …, 2018 - academic.oup.com
Abstract STUDY QUESTION In PGS, does chromosomal constitution differ among
trophectoderm (TE) biopsy sites and between them and the inner cell mass (ICM) …

Healthy live births from transfer of low-mosaicism embryos after preimplantation genetic testing for aneuploidy

CI Lee, EH Cheng, MS Lee, PY Lin, YC Chen… - Journal of Assisted …, 2020 - Springer
Purpose This study evaluated the potential viability of embryos with low mosaicism level (<
50%) by comparing the clinical outcomes of single mosaic versus euploid blastocyst …