Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic
byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the …

Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …

Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from
Archea to man. Thioredoxins, with a dithiol/disulfide active site (CGPC) are the major cellular …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

For a long time mitochondria have mainly been considered for their role in the aerobic
energy production in eukaryotic cells, being the sites of the oxidative phosphorylation, which …

BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …

Mammalian thioredoxin reductases (TrxR) are homodimers, homologous to glutathione
reductase (GR), with an essential selenocysteine (SeCys) residue in an extension …

The thioredoxin system—formed by thioredoxin reductase and its characteristic substrate
thioredoxin—is an important constituent of the intracellular redox milieu. Interactions with …

This study examines the basis of resistance and sensitivity of normal and transformed cells
to histone deacetylase inhibitor (HDACi)-induced cell death, specifically the role of caspases …