Lifelong restructuring of 3D genome architecture in cerebellar granule cells

L Tan, J Shi, S Moghadami, B Parasar, CP Wright… - Science, 2023 - science.org
The cerebellum contains most of the neurons in the human brain and exhibits distinctive
modes of development and aging. In this work, by developing our single-cell three …

GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells

T Zhou, R Zhang, D Jia, RT Doty, AD Munday, D Gao… - Nature Genetics, 2024 - nature.com
The organization of mammalian genomes features a complex, multiscale three-dimensional
(3D) architecture, whose functional significance remains elusive because of limited single …

[HTML][HTML] Cerebellar granule cells develop non-neuronal 3D genome architecture over the lifespan

L Tan, J Shi, S Moghadami, CP Wright, B Parasar… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The cerebellum contains most of the neurons in the human brain, and exhibits unique
modes of development, malformation, and aging. For example, granule cells—the most …

[HTML][HTML] Concurrent profiling of multiscale 3D genome organization and gene expression in single mammalian cells

T Zhou, R Zhang, D Jia, RT Doty, AD Munday, D Gao… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The organization of mammalian genomes within the nucleus features a complex, multiscale
three-dimensional (3D) architecture. The functional significance of these 3D genome …