The main aim of this review is to summarize and discuss the current state of knowledge on
chemical toxicity and radioactivity of depleted uranium (DU) and their effect on living …

Chromosomal translocations and genomic instability are universal hallmarks of tumor cells.
While the molecular mechanisms leading to the formation of translocations are rapidly being …

After mitosis, mammalian chromosomes partially decondense to occupy distinct territories in
the cell nucleus. Current models propose that territories are separated by an interchromatin …

Genomes are housed within cell nuclei as individual chromosome territories. Nuclei contain
several architectural structures that interact and influence the genome. In this review, we …

The formation and spatial arrangement of chromosome territories (CTs) in interphase has
been posited to influence the outcome and frequency of genomic translocations. This is …

Centromeres of Candida albicans form on unique and different DNA sequences but a
closely related species, Candida tropicalis, possesses homogenized inverted repeat (HIR) …

Radiation exposure is an occupational hazard for military personnel, some health care
professionals, airport security screeners, and medical patients, with some individuals at risk …

It is well established that chromosomes exist in discrete territories (CTs) in interphase and
are positioned in a cell-type specific probabilistic manner. The relative localisation of …

Recent imaging, molecular, and computational modeling studies have greatly enhanced our
knowledge of how eukaryotic chromosomes are folded in the nuclear space. This work has …

Higher-order organization of the human genome is well established with chromosomes
occupying distinct domains or territories in the interphase nucleus. Spatial organization of …