Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Inflammation and skeletal muscle wasting during cachexia

JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

COVID-19 and preexisting comorbidities: risks, synergies, and clinical outcomes

B Bigdelou, MR Sepand, S Najafikhoshnoo… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated
symptoms, named coronavirus disease 2019 (COVID-19), have rapidly spread worldwide …

Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Adipokine dysregulation and adipose tissue inflammation in human obesity

X Unamuno, J Gómez‐Ambrosi… - European journal of …, 2018 - Wiley Online Library
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Type 2 diabetes mellitus and psychological stress—a modifiable risk factor

RA Hackett, A Steptoe - Nature Reviews Endocrinology, 2017 - nature.com
Psychological stress is common in many physical illnesses and is increasingly recognized
as a risk factor for disease onset and progression. An emerging body of literature suggests …

Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies

P Manna, SK Jain - Metabolic syndrome and related disorders, 2015 - liebertpub.com
Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …

How UV light touches the brain and endocrine system through skin, and why

AT Slominski, MA Zmijewski, PM Plonka… - …, 2018 - academic.oup.com
The skin, a self-regulating protective barrier organ, is empowered with sensory and
computing capabilities to counteract the environmental stressors to maintain and restore …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …