[HTML][HTML] Regulation of the host immune system by helminth parasites

RM Maizels, HJ McSorley - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

Immunomodulation by helminth parasites: defining mechanisms and mediators

HJ McSorley, JP Hewitson, RM Maizels - International journal for …, 2013 - Elsevier
Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity

G Coakley, JL McCaskill, JG Borger, F Simbari… - Cell reports, 2017 - cell.com
Recent studies have demonstrated that many parasites release extracellular vesicles (EVs),
yet little is known about the specific interactions of EVs with immune cells or their functions …

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

LA Reynolds, KJ Filbey, RM Maizels - Seminars in immunopathology, 2012 - Springer
Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent
model of the immunology of gastrointestinal helminth infections of humans and livestock. It is …

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) …

JP Hewitson, Y Harcus, J Murray, M van Agtmaal… - Journal of …, 2011 - Elsevier
The intestinal helminth parasite, Heligmosomoides polygyrus bakeri offers a tractable
experimental model for human hookworm infections such as Ancylostoma duodenale and …

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

KJ Filbey, JR Grainger, KA Smith… - Immunology and cell …, 2014 - Wiley Online Library
The nematode Heligmosomoides polygyrus is an excellent model for intestinal helminth
parasitism. Infection in mice persists for varying lengths of time in different inbred strains …

Epidermal growth factor receptor expression licenses type-2 helper T cells to function in a T cell receptor-independent fashion

CM Minutti, S Drube, N Blair, C Schwartz, JC McCrae… - Immunity, 2017 - cell.com
Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which
induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby …

Immune modulation and modulators in Heligmosomoides polygyrus infection

RM Maizels, JP Hewitson, J Murray, YM Harcus… - Experimental …, 2012 - Elsevier
The intestinal nematode parasite Heligmosomoides polygyrus bakeri exerts widespread
immunomodulatory effects on both the innate and adaptive immune system of the host …

Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products

CJC Johnston, E Robertson, Y Harcus… - JoVE (Journal of …, 2015 - jove.com
Heligmosomoides polygyrus (formerly known as Nematospiroides dubius, and also referred
to by some as H. bakeri) is a gastrointestinal helminth that employs multiple …

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth H eligmosomoides polygyrus

HJ McSorley, MT O'Gorman, N Blair… - European journal of …, 2012 - Wiley Online Library
Allergic asthma is less prevalent in countries with parasitic helminth infections, and mice
infected with parasites such as H eligmosomoides polygyrus are protected from allergic …