Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …

In addition, women who have undergone bilateral oophorectomy under the age of 45 years
have been observed to be at increased risk of mortality from cardiovascular disease …

Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

The delay in childbearing is an important societal change contributing to an increasing
incidence of subfertility. The prevailing concept of female reproductive ageing assumes that …

A woman has an increased risk of breast cancer if her lifelong estrogen exposure is
increased due to an early menarche, a late menopause, and/or an absence of childbearing …

An unprecedented number of women will experience menopause in the next decade.
Although the timing of menopause affects long-term disease risk, little is known about factors …

Objective: There is increasing laboratory evidence for a neuroprotective effect of estrogen;
however, the clinical and epidemiologic evidence remains limited and conflicting. We …

В доступной форме в книге изложены основные события, произошедшие в
медицинской генетике и в молекулярной медицине после расшифровки генома …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …