Covering: up to August 2001This review covers the structure and function of heparin and
heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including …

Heparanases are endoglycosidases that cleave the heparan sulfate glycosaminoglycans
from proteoglycan core proteins and degrade them to small oligosaccharides. Inside cells …

The colonic epithelium provides an interface between the host and micro‐organisms
colonising the gastrointestinal tract. Molecular recognition of bacteria is facilitated through …

Purpose: Heparan sulfate proteoglycans have been implicated in cancer cell growth,
invasion, metastasis, and angiogenesis. This study was designed to compare their …

Perlecan is a major heparan sulfate proteoglycan (HSPG) of basement membranes (BMs)
and connective tissues. The core protein of perlecan is divided into five domains based on …

Human basement membrane heparan sulfate proteoglycan (HSPG) perlecan binds and
activates fibroblast growth factor (FGF)-2 through its heparan sulfate (HS) chains. Here we …

Osteoarthritis, the most common form of arthritis, is a debilitating progressive disease
principally affecting the elderly. Osteoarthritis therapy has evolved in the past few decades …

Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS
modifications might be potential targets to influence tumor development. We applied the …

Cell surface heparan sulfate proteoglycans (HSPGs) participate in the catabolism of many
physiologically important ligands. We previously reported that syndecan HSPGs directly …

Glycosylation changes occur widely in colon tumours, suggesting glycosylated molecules as
potential biomarkers for colon cancer diagnostics. In this study, proteoglycans (PGs) …