The chronic character of chemogenetics has been put forward as one of the assets of the
technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic …

Recombinant AAV (rAAV) is the most used delivery vector for clinical gene therapy.
However, many issues must be addressed before safer and more widespread …

Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are
critically involved in neural function. Genetically manipulating astrocytes is an essential tool …

It remains a fundamental challenge to administer guided regeneration and functional
recovery of peripheral nerves after the complete transection. Herein, a new concept to …

Dopamine cells in the ventral tegmental area (VTA DA) are critical for a variety of motivated
behaviors. These cells receive synaptic inputs from over 100 anatomically defined brain …

Early neural activity in the developing sensory system comprises spontaneous bursts of
patterned activity, which is fundamental for sculpting and refinement of immature cortical …

Recombinant adeno-associated viruses (AAVs) allow rapid and efficient gene delivery to the
nervous system, are widely used in neuroscience research, and are the basis of FDA …

Recombinant adeno-associated virus (rAAV) is the leading platform for delivering genetic
constructs in vivo. To date, three AAV-based gene therapeutic agents have been approved …

Hilar mossy cells regulate network function in the hippocampus through both direct
excitation and di-synaptic inhibition of dentate granule cells (DGCs). Substantial mossy cell …

Direct neuronal reprogramming is a promising approach to replace neurons lost due to
disease via the conversion of endogenous glia reacting to brain injury into neurons …