Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four
distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

Regeneration requires the coordination of stem cells, their progeny and distant differentiated
tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea …

Genes dedicated to killing cells must have evolved because of their positive effects on
organismal survival. Positive functions of apoptotic genes have been well established in a …

Hydra's almost unlimited regenerative potential is based on Wnt signaling, but so far it is
unknown how the injury stimulus is transmitted to discrete patterning fates in head and foot …

The discovery of Hydra regeneration by Abraham Trembley in 1744 promoted much
scientific curiosity thanks to his clever design of experimental strategies away from the …

The freshwater polyp Hydra provides a potent model system for investigating the conditions
that promote wound healing, reactivation of a developmental process and, ultimately …

Background Wound healing is the first stage of a series of cellular events that are necessary
to initiate a regenerative response. Defective wound healing can block regeneration even in …