Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

The conditioned place preference (CPP) paradigm is a well-established model utilized to
study the role of context associations in reward-related behaviors, including both natural …

Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome
also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is …

Astrocytes and neurons extensively interact in the brain. Identifying astrocyte and neuron
proteomes is essential for elucidating the protein networks that dictate their respective …

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …

Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering
motivational strength and decreased ability to control the desire to obtain drugs. In this …

OBJECTIVE: Epidemiological studies indicate that experimentation with addictive drugs and
onset of addictive disorders is primarily concentrated in adolescence and young adulthood …

Of the many conceptual distinctions present in psychology today, the approach-avoidance
distinction stands out as one of, if not the, most fundamental and basic. The distinction …