We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C)
that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme …

Schistosomiasis, a severe parasitic disease, is primarily caused by Schistosoma mansoni,
Schistosoma japonicum, or Schistosoma haematobium. Currently, praziquantel is the only …

Background The possible emergence of resistance to the only available drug for
schistosomiasis spurs drug discovery that has been recently incentivized by the availability …

Papain-like cysteine proteases bear an enormous potential as drug discovery targets for
both infectious and systemic human diseases. The considerable progress in this field over …

Background Schistosoma mekongi is a human blood fluke causing schistosomiasis that
threatens approximately 1.5 million humans in the world. Nonetheless, the limited available …

Chemotherapy based on repeated doses of praziquantel remains the most effective control
strategy against schistosomiasis, a neglected tropical disease caused by platyhelminths of …

Background Schistosoma flatworm parasites cause schistosomiasis, a chronic and
debilitating disease of poverty in developing countries. Praziquantel is employed for …

Schistosomiasis caused by a parasitic blood fluke of the genus Schistosoma afflicts over 200
million people worldwide. Schistosoma mansoni cathepsin B1 (SmCB1) is a gut-associated …

Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the
most used, fast, and reproducible method to confirm large-scale gene expression data. The …

The mevalonate pathway is essential in eukaryotes and responsible for a diversity of
fundamental synthetic activities. 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) …