Cancer is one of the most significant diseases associated with chronic alcohol consumption,
and chronic drinking is a strong risk factor for cancer, particularly of the upper aerodigestive …

Genetic information is encoded not only by the linear sequence of DNA, but also by
epigenetic modifications of chromatin structure that include DNA methylation and covalent …

Epithelial–mesenchymal transition (EMT) is a key process in tumor metastatic cascade that
is characterized by the loss of cell–cell junctions and cell polarity, resulting in the acquisition …

Purpose: Squamous cell carcinoma of the oral cavity is one of the most common human
neoplasms, and prevention of these carcinomas requires a better understanding of the …

Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of
human cancer, with an annual incidence of more than 500,000 cases worldwide. In the …

Cancer is one of the most devastating disorders in our lives. Higher rate of proliferation than
death of cells is one of the essential factors for development of cancer. The dynamicity of cell …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Genetic alterations that lead to loss or changes in tumour-suppressor genes are known to
contribute to oral carcinogenesis. Traditional molecular methods to detect such losses have …

Background MicroRNA (miRNA) expression is broadly altered in cancer, but few studies
have investigated miRNA deregulation in oral squamous cell carcinoma (OSCC). Epigenetic …

Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract
and can destroy the structure and function of organs involved in voice, speech, taste, smell …