Interferences in immunoassays: review and practical algorithm

L Wauthier, M Plebani, J Favresse - Clinical Chemistry and …, 2022 - degruyter.com
Immunoassays are currently the methods of choice for the measurement of a large panel of
complex and heterogenous molecules owing to full automation, short turnaround time, high …

[HTML][HTML] Clinical utility of laboratory developed mass spectrometry assays for steroid hormone testing

D French - Journal of Mass Spectrometry and Advances in the …, 2023 - Elsevier
It has long been recognized that immunoassays cannot accurately quantify steroid
hormones such as testosterone, estradiol, and aldosterone in certain patient populations …

The saline infusion test for primary aldosteronism: implications of immunoassay inaccuracy

G Eisenhofer, M Kurlbaum, M Peitzsch… - The Journal of …, 2022 - academic.oup.com
Context Diagnosis of primary aldosteronism (PA) for many patients depends on positive
results for the saline infusion test (SIT). Plasma aldosterone is often measured by …

Plasma steroid profiling in patients with adrenal incidentaloma

K Berke, G Constantinescu, J Masjkur… - The Journal of …, 2022 - academic.oup.com
Context Most patients with adrenal incidentaloma have nonfunctional lesions that do not
require treatment, while others have functional or malignant tumors that require intervention …

Fast accurate quantification of salivary cortisol and cortisone in a large-scale clinical stress study by micro-UHPLC-ESI-MS/MS using a surrogate calibrant approach

E Aydin, B Drotleff, H Noack, B Derntl… - … of Chromatography B, 2021 - Elsevier
Cortisol and cortisone are common markers for stress and thus preferentially analyzed in
matrices that allow non-invasive sampling such as saliva. Though the major drawback of …

Saline suppression to distinguish the primary aldosteronism subtype: a diagnostic study

H Hashimura, J Hu, H Kobayashi… - European Journal of …, 2023 - academic.oup.com
Objectives The saline suppression test (SST) serves to confirm the diagnosis of primary
aldosteronism (PA), while adrenal vein sampling (AVS) is used to subtype PA as unilateral …

Screening for Primary Aldosteronism by Mass Spectrometry Versus Immunoassay Measurements of Aldosterone: A Prospective Within-Patient Study

S Fuld, G Constantinescu, C Pamporaki… - The Journal of …, 2024 - academic.oup.com
Background Measurements of aldosterone by mass spectrometry are more accurate and
less prone to interferences than immunoassay measurements, and may produce a more …

DHEAS and differential blood counts as indirect signs of glucocorticoid excess in adrenal non-producing adenomas

EP Winzinger, H Jandikova, M Haase… - Hormone and …, 2021 - thieme-connect.com
The majority of incidentally discovered adrenal tumors are later characterized as non-
producing adrenocortical adenomas (NPA). We asked whether laboratory abnormalities in …

Primaarin aldosteronismin diagnostiikka ja hoito

PI Nevalainen, A Ylänen, E Hämäläinen, I Pörsti… - 2022 - dspace.uef.fi
Primaari aldosteronismi (PA) on yleisin hoidettava mutta alidiagnosoitu sekundaarisen
hypertension syy. Essentiaaliseen verenpainetautiin verrattuna se aiheuttaa selvästi …

[PDF][PDF] Incidentially discovered adrenal non-producing adenomas do show signs of glucocorticoid excess

EP Winzinger - 2022 - d-nb.info
Historically, the first proof of the existence of the suprarenal glands was given by Leonardo
da Vinci in 1550 when he realized the first drawing of the adrenal glands but the first written …