Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing
robust cardiovascular tissue engineering strategies, which enable synthetic or biological …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel
wall and normally adopt a quiescent, contractile phenotype. VSMC migration is tightly …

In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …

We expect that multiscale simulations will be one of the main high performance computing
workloads in the exascale era. We propose multiscale computing patterns as a generic …

Background and objective In-stent restenosis (ISR) following percutaneous coronary
intervention with drug-eluting stent (DES) implantation remains an unresolved issue, with …

Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …

Abstract Development and application of advanced mechanical models of soft tissues and
their growth represent one of the main directions in modern mechanics of solids. Such …

In-stent restenosis in superficial femoral arteries (SFAs) is a complex, multi-factorial and
multiscale vascular adaptation process whose thorough understanding is still lacking …

Since the introduction of percutaneous coronary intervention (PCI) for the treatment of
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …

In-stent restenosis (ISR) is one of the main drawbacks of stent implementation which limits
the long-term success of the procedure. Morphological changes occurring within the arterial …