Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of
UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes …

The platinum-based drug cisplatin is a widely used first-line therapy for several cancers.
Cisplatin interacts with DNA mainly in the form of Pt-d (GpG) di-adduct, which stalls cell …

The article presents the result of a study which examined DNA repair through photolyase in
Escherichia coli and nucleotide excision repair in both microorganism and humans. The …

We developed a method for genome-wide mapping of DNA excision repair named XR-seq
(excision repair sequencing). Human nucleotide excision repair generates two incisions …

The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

Cisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer
cells cope with the drug by removal of the damages with nucleotide excision repair. We have …

Formation and repair of UV-induced DNA damage in human cells are affected by cellular
context. To study factors influencing damage formation and repair genome-wide, we …

We recently developed a high-resolution genome-wide assay for mapping DNA excision
repair named eXcision Repair-sequencing (XR-seq) and have now used XR-seq to …

The circadian clock is a global regulatory system that interfaces with most other regulatory
systems and pathways in mammalian organisms. Investigations of the circadian clock–DNA …