Inflammatory responses after ischemic stroke

JH DeLong, SN Ohashi, KC O'Connor… - Seminars in …, 2022 - Springer
Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin

TA Pollak, BR Lennox, S Müller, ME Benros… - The Lancet …, 2020 - thelancet.com
There is increasing recognition in the neurological and psychiatric literature of patients with
so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) …

Gut-educated IgA plasma cells defend the meningeal venous sinuses

Z Fitzpatrick, G Frazer, A Ferro, S Clare, N Bouladoux… - Nature, 2020 - nature.com
The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system

J Dalmau, C Geis, F Graus - Physiological reviews, 2017 - journals.physiology.org
Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

[HTML][HTML] Association of cerebrospinal fluid brain-binding autoantibodies with cognitive impairment in post-COVID-19 syndrome

C Franke, F Boesl, Y Goereci, A Gerhard… - Brain, Behavior, and …, 2023 - Elsevier
Background Neurological symptoms, in particular cognitive deficits, are common in post-
COVID-19 syndrome (PCS). There is no approved therapy available, and the underlying …

Single-cell RNA sequencing of peripheral blood reveals immune cell signatures in Alzheimer's disease

H Xu, J Jia - Frontiers in immunology, 2021 - frontiersin.org
The peripheral immune system is thought to affect the pathology of the central nervous
system in Alzheimer's disease (AD). However, current knowledge is inadequate for …

[HTML][HTML] Biomarkers for the early detection and progression of Alzheimer's disease

SE Counts, MD Ikonomovic, N Mercado, IE Vega… - …, 2017 - Elsevier
The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …

Anti-NMDA receptor encephalitis, autoimmunity, and psychosis

MS Kayser, J Dalmau - Schizophrenia research, 2016 - Elsevier
Abstract Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a recently-discovered
synaptic autoimmune disorder in which auto-antibodies target NMDARs in the brain, leading …

Clinical and pathogenic significance of IgG, IgA, and IgM antibodies against the NMDA receptor

M Hara, E Martinez-Hernandez, H Ariño, T Armangué… - Neurology, 2018 - AAN Enterprises
Objective To determine the frequency and clinical relevance of immunoglobulin (Ig) G, IgA,
and IgM N-methyl-d-aspartate receptor (NMDAR) antibodies in several diseases, and …

Human cerebrospinal fluid monoclonal N -methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

J Kreye, NK Wenke, M Chayka, J Leubner, R Murugan… - Brain, 2016 - academic.oup.com
Abstract See Zekeridou and Lennon (doi: 10.1093/aww213) for a scientific commentary on
this article. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently …