Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …

Dimethyl fumarate (DMF) is a small molecule currently approved and used in the treatment
of psoriasis and multiple sclerosis due to its immuno-modulatory, anti-inflammatory, and …

The retinal pigment epithelium (RPE) is consistently exposed to high levels of pro-oxidant
and inflammatory stimuli. As such, under normal conditions the antioxidant machinery in the …

Oxidative damage has been identified as a major causative factor in degenerative diseases
of the retina; retinal pigment epithelial (RPE) cells are at high risk. Hence, identifying novel …

Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor
erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Purpose: We determine if monomethyl fumarate (MMF) can protect the retina in mice
subjected to light-induced retinopathy (LIR). Methods: Albino BALB/c mice were …

Preservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it
is not surprising that loss of barrier integrity is a pathologic feature common to degenerative …

Sickle cell disease (SCD) is an inheritable hemoglobinopathy characterized by
polymerization of hemoglobin S in red blood cells resulting in chronic hemolytic anemia …

Purpose: Activating the cell survival modulator sigma 1 receptor (Sig1R) delays cone
photoreceptor cell loss in Pde6βrd10/J (rd10) mice, a model of retinitis pigmentosa …