The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments

G Targher, KE Corey, CD Byrne… - … reviews Gastroenterology & …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

Pathophysiological, molecular and therapeutic issues of nonalcoholic fatty liver disease: an overview

S Marchisello, A Di Pino, R Scicali, F Urbano… - International journal of …, 2019 - mdpi.com
Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

Z Liu, Y Zhang, S Graham, X Wang, D Cai, M Huang… - Journal of …, 2020 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and
obesity are epidemiologically correlated with each other but the causal inter-relationships …

Metabolic-associated fatty liver disease (MAFLD), diabetes, and cardiovascular disease: Associations with fructose metabolism and gut microbiota

K Drożdż, K Nabrdalik, W Hajzler, H Kwiendacz… - Nutrients, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition associated
with type 2 diabetes (T2DM) and cardiovascular disease (CVD). Since systemic metabolic …

[HTML][HTML] Hepatokines and adipokines in NASH-related hepatocellular carcinoma

O Kucukoglu, JP Sowa, GD Mazzolini, WK Syn… - Journal of …, 2021 - Elsevier
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Epidemiology and pathophysiology of the association between NAFLD and metabolically healthy or metabolically unhealthy obesity

A Lonardo, A Mantovani, S Lugari, G Targher - Annals of hepatology, 2020 - Elsevier
The prevalence of nonalcoholic fatty liver disease (NAFLD) is continuing to rise in many
countries, paralleling the epidemic of obesity worldwide. In the last years, the concept of …

Sexual dimorphism of NAFLD in adults. Focus on clinical aspects and implications for practice and translational research

A Lonardo, A Suzuki - Journal of clinical medicine, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) embraces the clinico-pathological consequences
of hepatic lipotoxicity and is a major public health problem globally. Sexual dimorphism is a …

Perspectives on precision medicine approaches to NAFLD diagnosis and management

A Lonardo, JP Arab, M Arrese - Advances in Therapy, 2021 - Springer
Precision medicine defines the attempt to identify the most effective approaches for specific
subsets of patients based on their genetic background, clinical features, and environmental …

Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation

A Lonardo, A Mantovani, S Petta, A Carraro… - Nature Reviews …, 2022 - nature.com
The rising tide of non-alcoholic fatty liver disease (NAFLD) associated with the obesity
epidemic is a major health concern worldwide. NAFLD—specifically its more advanced form …