Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …

The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised
by hypogammaglobulinaemia, impaired production of specific antibodies after immunisation …

Primary antibody deficiencies (PADs) are the most common inherited immunodeficiencies in
humans. The use of novel approaches, such as whole-exome sequencing and mouse …

Starting about 60 years ago, a number of reports appeared that outlined the severe clinical
course of a few adult subjects with profound hypogammaglobinemia. Puzzled by the lack of …

Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody
production due to either molecular defects intrinsic to B-cells or a failure of interaction …