Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …

Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc.
The interactions between these components, which are divided into anti-tumor and pro …

Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …

Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable
(MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains …

Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells.
PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also …