Listen to an interview with Sean Morrison on the stem cells podcast Much has been made of
the idea that asymmetric cell division is a defining characteristic of stem cells that enables …

Cullin proteins are molecular scaffolds that have crucial roles in the post-translational
modification of cellular proteins involving ubiquitin. The mammalian cullin protein family …

The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of
ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to …

Genome sequencing projects generate a wealth of information; however, the ultimate goal of
such projects is to accelerate the identification of the biological function of genes. This …

This review summarizes recent advances concerning the Nedd8 regulatory pathway in four
areas. One, substantial progress has been made in delineating the role of cullin family …

The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

We report here the transcriptional profiling of the cell cycle on a genome-wide scale in
human fibroblasts. We identified approximately 700 genes that display transcriptional …

Hypoxia-inducible factor, a heterodimeric transcription complex, regulates cellular and
systemic responses to low oxygen levels (hypoxia) during normal mammalian development …

The first draft of the human genome sequence was reported a year ago. It may be a good
time to remind ourselves that the genetic information encoded in the∼ 3000-Mb sequence is …

Background: The inability to efficiently repair DNA damage or remove cells with severely
damaged genomes has been linked to several human cancers. Studies in yeasts and …