Physiological and pathophysiological insights of Nav1. 4 and Nav1. 5 comparison
G Loussouarn, D Sternberg, S Nicole… - Frontiers in …, 2016 - frontiersin.org
Mutations in Nav1. 4 and Nav1. 5 α-subunits have been associated with muscular and
cardiac channelopathies, respectively. Despite intense research on the structure and …
cardiac channelopathies, respectively. Despite intense research on the structure and …
The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction …
Abstract Aims Variants in SCN5A encoding Nav1. 5 are associated with cardiac arrhythmias.
We aimed to determine the mechanism by which c. 638G> A in SCNA5 resulting in p …
We aimed to determine the mechanism by which c. 638G> A in SCNA5 resulting in p …
Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors
ABSTRACT A 13 aa residue voltage‐gated sodium (Nav) channel inhibitor peptide, Pn,
containing 2 disulfide bridges was designed by using a chimeric approach. This approach …
containing 2 disulfide bridges was designed by using a chimeric approach. This approach …
Multifocal ectopic purkinje-related premature contractions and related cardiomyopathy
K Calloe, HBD Magnusson, DL Lildballe… - Frontiers in …, 2023 - frontiersin.org
In the past 20 years, genetic variants in SCN5A encoding the cardiac voltage-gated sodium
channel Nav1. 5 have been linked to a range of inherited cardiac arrhythmias: variants …
channel Nav1. 5 have been linked to a range of inherited cardiac arrhythmias: variants …
PCID: a novel approach for predicting disease comorbidity by integrating multi-scale data
Disease comorbidity is the presence of one or more diseases along with a primary disorder,
which causes additional pain to patients and leads to the failure of standard treatments …
which causes additional pain to patients and leads to the failure of standard treatments …
Role of the voltage sensor module in Nav domain IV on fast inactivation in sodium channelopathies: The implication of closed-state inactivation
T Nakajima, Y Kaneko, T Dharmawan, M Kurabayashi - Channels, 2019 - Taylor & Francis
ABSTRACT The segment 4 (S4) voltage sensor in voltage-gated sodium channels (Navs)
have domain-specific functions, and the S4 segment in domain DIV (DIVS4) plays a key role …
have domain-specific functions, and the S4 segment in domain DIV (DIVS4) plays a key role …
Fluorescent visualization of cellular proton fluxes
Cells use plasma membrane proton fluxes to maintain cytoplasmic and extracellular pH and
to mediate the co-transport of metabolites and ions. Because proton-coupled transport often …
to mediate the co-transport of metabolites and ions. Because proton-coupled transport often …
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders
C Jorgensen - Journal of General Physiology, 2025 - rupress.org
In this issue of the Journal of General Physiology, authors from the University of Mississippi
led by Eslam Elhanafy and colleagues in the group of Prof. Jing Li use a combination of …
led by Eslam Elhanafy and colleagues in the group of Prof. Jing Li use a combination of …
Noncanonical ion channel behaviour in pain
Ion channels contribute fundamental properties to cell membranes. Although highly diverse
in conductivity, structure, location, and function, many of them can be regulated by common …
in conductivity, structure, location, and function, many of them can be regulated by common …