Physiological and pathophysiological insights of Nav1. 4 and Nav1. 5 comparison

G Loussouarn, D Sternberg, S Nicole… - Frontiers in …, 2016 - frontiersin.org
Mutations in Nav1. 4 and Nav1. 5 α-subunits have been associated with muscular and
cardiac channelopathies, respectively. Despite intense research on the structure and …

Genetics of dilated cardiomyopathy

Y Fu, HJ Eisen - Current cardiology reports, 2018 - Springer
Abstract Purpose of Review Dilated cardiomyopathy (DCM) is characterized by left
ventricular dilation and systolic function and is the most common among all …

The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction …

K Calloe, M Geryk, K Freude, JA Treat, VA Vold… - Europace, 2022 - academic.oup.com
Abstract Aims Variants in SCN5A encoding Nav1. 5 are associated with cardiac arrhythmias.
We aimed to determine the mechanism by which c. 638G> A in SCNA5 resulting in p …

Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors

S Peigneur, O Cheneval, M Maiti, E Leipold… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT A 13 aa residue voltage‐gated sodium (Nav) channel inhibitor peptide, Pn,
containing 2 disulfide bridges was designed by using a chimeric approach. This approach …

Multifocal ectopic purkinje-related premature contractions and related cardiomyopathy

K Calloe, HBD Magnusson, DL Lildballe… - Frontiers in …, 2023 - frontiersin.org
In the past 20 years, genetic variants in SCN5A encoding the cardiac voltage-gated sodium
channel Nav1. 5 have been linked to a range of inherited cardiac arrhythmias: variants …

PCID: a novel approach for predicting disease comorbidity by integrating multi-scale data

F He, G Zhu, YY Wang, XM Zhao… - IEEE/ACM transactions …, 2016 - ieeexplore.ieee.org
Disease comorbidity is the presence of one or more diseases along with a primary disorder,
which causes additional pain to patients and leads to the failure of standard treatments …

Role of the voltage sensor module in Nav domain IV on fast inactivation in sodium channelopathies: The implication of closed-state inactivation

T Nakajima, Y Kaneko, T Dharmawan, M Kurabayashi - Channels, 2019 - Taylor & Francis
ABSTRACT The segment 4 (S4) voltage sensor in voltage-gated sodium channels (Navs)
have domain-specific functions, and the S4 segment in domain DIV (DIVS4) plays a key role …

Fluorescent visualization of cellular proton fluxes

L Zhang, K Bellve, K Fogarty, WR Kobertz - Cell chemical biology, 2016 - cell.com
Cells use plasma membrane proton fluxes to maintain cytoplasmic and extracellular pH and
to mediate the co-transport of metabolites and ions. Because proton-coupled transport often …

Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders

C Jorgensen - Journal of General Physiology, 2025 - rupress.org
In this issue of the Journal of General Physiology, authors from the University of Mississippi
led by Eslam Elhanafy and colleagues in the group of Prof. Jing Li use a combination of …

Noncanonical ion channel behaviour in pain

CI Ciotu, C Tsantoulas, J Meents, A Lampert… - International Journal of …, 2019 - mdpi.com
Ion channels contribute fundamental properties to cell membranes. Although highly diverse
in conductivity, structure, location, and function, many of them can be regulated by common …