Synthetic analogues relevant to the structure and function of zinc enzymes
G Parkin - Chemical Reviews, 2004 - ACS Publications
Zinc is essential to all forms of life, 1-4 with an average adult human containing ca. 3 g of
zinc. 5 For example, zinc is indispensable for effective growth and development, has …
zinc. 5 For example, zinc is indispensable for effective growth and development, has …
Copper (II), zinc (II) and nickel (II) complexes as nuclease mimetics
D Desbouis, IP Troitsky, MJ Belousoff, L Spiccia… - Coordination Chemistry …, 2012 - Elsevier
The manipulation of phosphate ester linkages is very important in the chemistry of life. Cells
possess highly evolved enzymatic machinery to make and break these linkages, which are …
possess highly evolved enzymatic machinery to make and break these linkages, which are …
Progress in artificial metallonucleases
The development of synthetic agents able to hydrolytically cleave DNA with high efficiency
and selectivity is still a fascinating challenge. Over the years, many examples have been …
and selectivity is still a fascinating challenge. Over the years, many examples have been …
Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering
BS Der, DR Edwards, B Kuhlman - Biochemistry, 2012 - ACS Publications
Here we show that a recent computationally designed zinc-mediated protein interface is
serendipitously capable of catalyzing carboxyester and phosphoester hydrolysis. Although …
serendipitously capable of catalyzing carboxyester and phosphoester hydrolysis. Although …
[图书][B] From enzyme models to model enzymes
AJ Kirby, F Hollfelder - 2009 - books.google.com
Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is one
of the great challenges facing science today. Our current level of understanding fails the …
of the great challenges facing science today. Our current level of understanding fails the …
Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst
R Bonomi, F Selvestrel, V Lombardo… - Journal of the …, 2008 - ACS Publications
Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst | Journal
of the American Chemical Society ACS ACS Publications C&EN CAS Find my institution Log In …
of the American Chemical Society ACS ACS Publications C&EN CAS Find my institution Log In …
Zinc (II) complexes as hydrolytic catalysts of phosphate diester cleavage: from model substrates to nucleic acids
The development of synthetic agents able to hydrolytically cleave phosphate diester bonds
with high efficiency is a fascinating challenge, which will ultimately open the way to artificial …
with high efficiency is a fascinating challenge, which will ultimately open the way to artificial …
Toward efficient Zn (II)-based artificial nucleases
E Boseggia, M Gatos, L Lucatello… - Journal of the …, 2004 - ACS Publications
A series of cis-cis-triaminocyclohexane Zn (II) complex− anthraquinone intercalator
conjugates, designed in such a way to allow their easy synthesis and modification, have …
conjugates, designed in such a way to allow their easy synthesis and modification, have …
K6[P2Mo18O62] as DNase-Mimetic Artificial Nucleases to Promote Extracellular Deoxyribonucleic Acid Degradation in Bacterial Biofilms
In the current study, the DNase-like activity of the Dawson-type polyoxometalate K6
[P2Mo18O62] was explored. The obtained findings demonstrated that K6 [P2Mo18O62] …
[P2Mo18O62] was explored. The obtained findings demonstrated that K6 [P2Mo18O62] …
Correlation of structure and function in oligonuclear zinc (II) model phosphatases
A series of pyrazolate-based dizinc (II) complexes has been synthesized and investigated as
functional models for phosphoesterases, focusing on correlations between hydrolytic activity …
functional models for phosphoesterases, focusing on correlations between hydrolytic activity …