The surface of the eye provides an inert barrier against infection. Through its unique
combination of antimicrobial action and anti-inflammatory activities lactoferrin (Lf) in the tear …

Importance of the field: There exists a considerable unmet need for more efficacious delivery
of ocular therapeutics. Contact lenses have been developed with high loading and …

The aim of the subcommittee report was to review published evidence describing tear film
changes secondary to contact lens wear and to examine the evidence for associations …

Examining the role of the contact lens material, design, and the care system is fundamental
to understanding contact lens discomfort (CLD). However, a systematic review that tries to …

The first citation in PubMed referencing the issue of comfort with contact lenses is a paper
from 1960 linking hygienic contact lens care and comfortable lens wear. 1 Unfortunately, not …

Contact lens materials have undergone significant changes over the past 20 years,
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …

Zero-order or concentration independent release kinetics are highly desirable from drug
delivery devices. In this paper we demonstrate experimentally, for the first time, zero-order …

Purpose Current dry eye treatment includes delivering comfort agents to the eye via drops,
but low bioavailability and multiple administration continues to be a barrier to effective …

Novel molecularly imprinted, therapeutic contact lenses capable of controlled release of the
non-steroidal anti-inflammatory (NSAID) diclofenac sodium were synthesized, exploiting …

This review describes the impact of contact lens wear on the tear film lipid layer and how
changes in the lipid layer might modulate contact lens-related discomfort. Relevant clinical …