Use of zebrafish in drug discovery toxicology

S Cassar, I Adatto, JL Freeman, JT Gamse… - Chemical research in …, 2019 - ACS Publications
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations

U Strähle, S Scholz, R Geisler, P Greiner… - Reproductive …, 2012 - Elsevier
Worldwide, the zebrafish has become a popular model for biomedical research and (eco)
toxicology. Particularly the use of embryos is receiving increasing attention, since they are …

Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio)

K Lu, R Qiao, H An, Y Zhang - Chemosphere, 2018 - Elsevier
As the accumulation of microplastics (MPs) in the environment continues to rise, more
concerns focus on the health risk of combined exposure to MPs and other contaminants. The …

Comparative toxicity analyses from different endpoints: are new cyclic disinfection byproducts (DBPs) more toxic than common aliphatic DBPs?

Y Wu, W Wei, J Luo, Y Pan, M Yang… - Environmental …, 2021 - ACS Publications
In recent years, dozens of halogenated disinfection byproducts (DBPs) with cyclic structures
were identified and detected in drinking water globally. Previous in vivo toxicity studies have …

Evaluation of Cr (VI) reduction mechanism and removal by Cellulosimicrobium funkei strain AR8, a novel haloalkaliphilic bacterium

C Karthik, S Barathi, A Pugazhendhi… - Journal of hazardous …, 2017 - Elsevier
The present study, a novel haloalkaliphilic Cr (VI) tolerant bacterial strain,
Cellulosimicrobium funkei AR8, was isolated and characterized for its high Cr (VI) reduction …

An updated review of toxicity effect of the rare earth elements (REEs) on aquatic organisms

N Malhotra, HS Hsu, ST Liang, MJM Roldan, JS Lee… - Animals, 2020 - mdpi.com
Simple Summary Rare earth elements (REEs) have become important metals in modern-
day technology. The process of discarding obsolete equipment containing REEs, use of …

Nanomaterials meet zebrafish: Toxicity evaluation and drug delivery applications

HR Jia, YX Zhu, QY Duan, Z Chen, FG Wu - Journal of Controlled Release, 2019 - Elsevier
With the rapid development of engineered nanomaterials for various applications, in vivo
toxicological studies for evaluating the potential hazardous effects of nanomaterials on …

The fish embryo test (FET): origin, applications, and future

T Braunbeck, B Kais, E Lammer, J Otte… - … Science and Pollution …, 2015 - Springer
Originally designed as an alternative for the acute fish toxicity test according to, eg, OECD
TG 203, the fish embryo test (FET) with the zebrafish (Danio rerio) has been optimized …

Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): a multi biomarker study

K Maharajan, S Muthulakshmi, B Nataraj, M Ramesh… - Aquatic Toxicology, 2018 - Elsevier
Abstract Pyriproxyfen (2-[1-methyl-2-(4-phenoxyphenoxy) ethoxy] pyridine)(PPF), a pyridine-
based pesticide widely used to control agricultural insect pests and mosquitoes in drinking …

Steroids in teleost fishes: A functional point of view

J Tokarz, G Möller, MH de Angelis, J Adamski - Steroids, 2015 - Elsevier
Steroid hormones are involved in the regulation of a variety of processes like embryonic
development, sex differentiation, metabolism, immune responses, circadian rhythms, stress …