The absence or damage of a tissue is the main cause of most acute or chronic diseases and
are one of the appealing challenges that novel therapeutic alternatives have, in order to …

Nanoparticles offer new opportunities for the treatment of skin diseases. The barrier function
of the skin poses a significant challenge for nanoparticles to permeate into the tissue …

Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often
opposing functions. The biological activities of this polysaccharide depend on its molecular …

Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …

Growing evidence suggests that transcriptional regulators and secreted RNA molecules
encapsulated within membrane vesicles modify the phenotype of target cells. Membrane …

Metastatic tumors have been shown to establish microenvironments in distant tissues that
are permissive to disseminated tumor cells. Hematopoietic cells contribute to this …

Organoids made from dissociated progenitor cells undergo tissue-like organization. This in
vitro self-organization process is not identical to embryonic organ formation, but it achieves a …

The natural extracellular matrix (ECM), thanks to its specific properties (eg, collagenous
lattice, a reservoir of growth factors, ECM‐cell anchoring areas, an optimal pH and CO2) …

An altered liver microenvironment characterized by a dysregulated extracellular matrix
(ECM) supports the development and progression of hepatocellular carcinoma (HCC). The …

The importance of context in regulation of gene expression is now an accepted principle; yet
the mechanism by which the microenvironment communicates with the nucleus and …