Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

There is a growing emphasis on the relationship between the complexity and diversity of the
microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease …

Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …

Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant
functional assays aimed at studying these failures and the efficacy of cancer immunotherapy …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the
immune system. Ligands of NKG2D are normally of low abundance, but can be induced in …

In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …

Inflammatory bowel diseases are characterized by a deregulated immune response
targeting the gut bacterial flora. Mucosal-associated invariant T (MAIT) cells are major …

IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and
intrinsic factors, including host genetics, the immune system, environmental factors and the …