Immunobiology and pathogenesis of hepatitis B virus infection

M Iannacone, LG Guidotti - Nature Reviews Immunology, 2022 - nature.com
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

Hepatitis B virus biology and life cycle

S Tsukuda, K Watashi - Antiviral research, 2020 - Elsevier
Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases.
The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double …

A global scientific strategy to cure hepatitis B

PA Revill, FV Chisari, JM Block, M Dandri… - The lancet …, 2019 - thelancet.com
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …

A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

A Kramvis, KM Chang, M Dandri, P Farci… - Nature Reviews …, 2022 - nature.com
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one
million people die annually from HBV-related causes, including liver cancer. Although there …

The scientific basis of combination therapy for chronic hepatitis B functional cure

SG Lim, TF Baumert, C Boni, E Gane… - Nature Reviews …, 2023 - nature.com
Functional cure of chronic hepatitis B (CHB)—or hepatitis B surface antigen (HBsAg) loss
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …

HBV DNA integration: molecular mechanisms and clinical implications

T Tu, MA Budzinska, NA Shackel, S Urban - Viruses, 2017 - mdpi.com
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity
and mortality. One peculiar observation in cells infected with HBV (or with closely‑related …

[PDF][PDF] Serum hepatitis B virus RNA: a new potential biomarker for chronic hepatitis B virus infection

S Liu, B Zhou, JD Valdes, J Sun, H Guo - Hepatology, 2019 - Wiley Online Library
Chronic hepatitis B infection is one of the major etiological causes of liver failure, cirrhosis,
and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured …

Hepatitis B virus entry into cells

C Herrscher, P Roingeard, E Blanchard - Cells, 2020 - mdpi.com
Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread
human pathogen responsible for more than 250 million chronic infections worldwide …

Revisiting hepatitis B virus: challenges of curative therapies

J Hu, U Protzer, A Siddiqui - Journal of virology, 2019 - Am Soc Microbiol
With a yearly death toll of 880,000, hepatitis B virus (HBV) remains a major health problem
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …

The role of cccDNA in HBV maintenance

L Allweiss, M Dandri - Viruses, 2017 - mdpi.com
Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide; it
can cause various degrees of liver damage and is strongly associated with the development …