Inorganic arsenic (iAs) at high exposures is a human carcinogen, affecting mainly the
urinary bladder, lung and skin. We present an assessment of the mode of action (MOA) of …

In recent years, research on the autophagic process has greatly increased, invading the
fields of biology and medicine. Several markers of the autophagic process have been …

Environmental and/or occupational exposure to metals such as Arsenic (As), Cadmium (Cd),
and Chromium (Cr) have been shown to induce carcinogenesis in various organs, including …

Beclin-1 is an essential autophagic regulator that plays diverse roles in physiology and
disease. However, reports about the function of fish Beclin-1 during pathogen infection are …

Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, which
has been linked to diverse biological processes including immunity, development, tumor …

In mammals, beclin-1 is a key player that regulates autophagic activity. In fish, the immune
function of beclin-1 is essentially unknown. In this study, we analyzed the involvement of …

Beclin 1 plays a critical role in the regulation of autophagy, apoptosis, differentiation, as well
as in the development and progression of cancer. The aim of this study was to examine the …

Beclin 1 plays an important role in autophagy and apoptosis which are well documented in
mammals. However, relevant reports are rare in fish. This study characterized Beclin 1 of the …

Epidemiological studies have established an association between arsenic exposure and the
development of bladder cancer. Studies in arsenic‐endemic areas such Taiwan, Chile, and …

The urinary bladder urothelium is subjected to mechanical forces during cycles of distension
and contraction, and its superficial cells are constantly flushed by toxic urine. Yet, the …