Animal models of arrhythmia: classic electrophysiology to genetically modified large animals

S Clauss, C Bleyer, D Schuettler, P Tomsits… - Nature Reviews …, 2019 - nature.com
Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

Thyroid hormone plays an important role in cardiac function: from bench to bedside

H Yamakawa, TS Kato, JY Noh, S Yuasa… - Frontiers in …, 2021 - frontiersin.org
Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood
to regulate cells, tissues, and organs in the body. In particular, they exert several effects on …

Animal models to study cardiac arrhythmias

DJ Blackwell, J Schmeckpeper… - Circulation research, 2022 - Am Heart Assoc
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Mechanisms and management of thyroid disease and atrial fibrillation: impact of atrial electrical remodeling and cardiac fibrosis

A Takawale, M Aguilar, Y Bouchrit, R Hiram - Cells, 2022 - mdpi.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with increased
cardiovascular morbidity and mortality. The pathophysiology of AF is characterized by …

The role of thyroid hormones in heart failure

C Vale, JS Neves, M von Hafe… - … drugs and therapy, 2019 - Springer
Cardiovascular diseases are the leading cause of death worldwide. Heart failure is the
terminal manifestation of cardiovascular diseases, and its morbidity and mortality remain …

CTRP9 ameliorates atrial inflammation, fibrosis, and vulnerability to atrial fibrillation in post‐myocardial infarction rats

M Liu, W Li, H Wang, L Yin, B Ye, Y Tang… - Journal of the …, 2019 - Am Heart Assoc
Background Inflammation and fibrosis play an important role in the pathogenesis of atrial
fibrillation (AF) after myocardial infarction (MI). CTRP9 (C1q/tumor necrosis factor‐related …

Similarities and differences in the peripheral actions of thyroid hormones and their metabolites

RA Louzada, DP Carvalho - Frontiers in endocrinology, 2018 - frontiersin.org
Thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) are secreted by the thyroid gland, while T3 is
also generated from the peripheral metabolism of T4 by iodothyronine deiodinases types I …

A Polypyrrole‐Polycarbonate Polyurethane Elastomer Alleviates Cardiac Arrhythmias via Improving Bio‐Conductivity

MR Fadle Aziz, L Wlodarek, F Alibhai… - Advanced …, 2023 - Wiley Online Library
Myocardial fibrosis, resulting from myocardial infarction (MI), significantly alters cardiac
electrophysiological properties. As fibrotic scar tissue forms, its resistance to incoming action …

Fisetin alleviates atrial inflammation, remodeling, and vulnerability to atrial fibrillation after myocardial infarction

L Liu, S Gan, B Li, X Ge, H Yu, H Zhou - International heart journal, 2019 - jstage.jst.go.jp
Atrial inflammation and fibrosis are the critical processes involved in atrial fibrillation (AF)
after myocardial infarction (MI). Fisetin is a dietary flavonoid that has shown forceful anti …

Identification of functional lncRNAs in atrial fibrillation by integrative analysis of the lncRNA‐mRNA network based on competing endogenous RNAs hypothesis

C Qian, H Li, D Chang, B Wei… - Journal of cellular …, 2019 - Wiley Online Library
A mounting body of evidence has suggested that long noncoding RNAs (lncRNAs) play
critical roles in human diseases by acting as competing endogenous RNAs (ceRNAs) …