Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …

Background Telomere shortening and alterations of mitochondrial biogenesis are involved
in cellular aging. Childhood adversity is associated with telomere shortening, and several …

Major depressive disorder (MDD) has been linked to mitochondrial defects, which could
manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

Aging is associated with complex biological changes that can be accelerated, slowed, or
even temporarily reversed by biological and non-biological factors. This article focuses on …

In seeking to understand mental health and disease, it is fundamental to identify the
biological substrates that draw together the experiences and physiological processes that …

Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …

Background Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic
molecule and a novel biomarker of psychiatric disorders. Some previous studies reported …

Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial
dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the …