The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …

Abstract Glucagon-like peptide 1 (GLP-1) is a hormone with essential roles in regulating
insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated …

Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …

Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple
diseases; however, there remains substantial interest in the development of orally delivered …

Class BG protein–coupled receptors, an important class of therapeutic targets, signal mainly
through the Gs class of heterotrimeric G proteins, although they do display some promiscuity …

Class BG protein-coupled receptors (GPCRs) are important therapeutic targets for major
diseases. Here, we present structures of peptide and Gs-bound pituitary adenylate cyclase …

The secretin-like class B family of G protein-coupled receptors (GPCRs) are key players in
hormonal homeostasis. Recent structures of various receptors in complex with a variety of …

Class BG protein-coupled receptors (GPCRs) are important targets in the treatment of
metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein …

Corticotropin-releasing factor (CRF) and the three related peptides urocortins 1–3 (UCN1–
UCN3) are endocrine hormones that control the stress responses by activating CRF1R and …