Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …

Muscle stem cells (MuSCs) reside in a specialized niche that ensures their regenerative
capacity. Although we know that innate immune cells infiltrate the niche in response to …

Following acute injury, stromal cells promote tissue regeneration by a diversity of
mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal …

Skeletal muscle possesses a remarkable capacity to regenerate when injured, but when
confronted with major traumatic injury resulting in volumetric muscle loss (VML), the …

Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and
persistent functional deficits which ultimately manifest disability. Acellular biological …

Subsequent to acute injury, skeletal muscle undergoes a stereotypic regenerative process
that reestablishes homeostasis. Various types of innate and adaptive immunocytes exert …

The concept of replenishing or elevating nicotinamide adenine dinucleotide (NAD+)
availability to combat metabolic disease and ageing (described extensively in recent …

Objective Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect
skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ …

Objectives: Complicated fracture healing is often associated with the severity of surrounding
muscle tissue trauma. Since inflammation is a primary determinant of musculoskeletal health …