Cholesterol transport from the outer to the inner mitochondrial membrane is the rate-
determining step in steroid and bile acid biosyntheses. Biochemical, pharmacological and …

Steroid hormones are synthesized in steroidogenic cells of the adrenal, ovary, testis,
placenta and brain and are essential for normal reproductive function and bodily …

This study investigated the roles of the protein kinase C (PKC) and protein kinase A (PKA)
pathways in regulating constitutive steroidogenesis and steroidogenic acute regulatory …

In the modern world, humans are exposed during their whole life to a large number of
synthetic chemicals. Some of these chemicals have the potential to disrupt endocrine …

Tumor cell targeted therapies, by induction or enhancement of apoptosis, constitute recent
promising approaches achieving more specific anti-tumor efficacy. The peripheral …

The peripheral benzodiazepine receptor (PBR), is an 18 kDa protein of the mammalian
mitochondrial membrane and is a highly conserved protein among the mammalian. PBR is …

LH increases the intracellular Ca2+ concentration ([Ca2+] i) in mice Leydig cells, in a
process triggered by calcium influx through T-type Ca2+ channels. Here we show that LH …

The range of in vivo or in vitro immortalized cell lines currently available provides a variety of
model systems for studies of normal and pathological cell functions. The cell lines have …

In the present study, steroidogenesis in two different Leydig tumor cell lines was compared.
One, the MA-10 mouse tumor cell line, produces steroids and the steroidogenic acute …

The peripheral-type benzodiazepine receptor (PBR), a putative receptor in Leydig cells,
modulates steroidogenesis. Since benzodiazepines are commonly used in regional …