Advanced peripheral diabetic neuropathy (PDN) is associated with elevated vibration and
thermal perception thresholds that progress to sensory loss and degeneration of all fiber …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …

Endometriosis-associated chronic pelvic pain (EACPP) presents with an intense
inflammatory reaction. Melatonin has emerged as an important analgesic, antioxidant, and …

AIMS: Melatonin is a hormone synthesized principally in the pineal gland that has been
classically associated with endocrine actions. However, several lines of evidence suggest …

The intensity of pain sensation exhibits marked day and night variations. Since the intensity
of pain perception is low during dark hours of the night when melatonin levels are high, this …

Melatonin is a circulating hormone that is mainly released from the pineal gland. It is best
known as a regulator of seasonal and circadian rhythms, its levels being high during the …

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in
vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms …

Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects
are mediated by receptors while other, like cytoprotection, seem to depend on direct and …

Neuropathic pain is an important public health problem for which only a few treatments are
available. Preclinical studies show that melatonin (MLT), a neurohormone acting on MT1 …