Biological signaling by carbon monoxide and carbon monoxide-releasing molecules

R Motterlini, R Foresti - American Journal of Physiology …, 2017 - journals.physiology.org
Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

[HTML][HTML] The diagnosis and treatment of carbon monoxide poisoning

L Eichhorn, M Thudium, B Jüttner - Deutsches Ärzteblatt …, 2018 - ncbi.nlm.nih.gov
Background The symptoms of carbon monoxide (CO) poisoning are nonspecific, ranging
from dizziness and headache to unconsciousness and death. A German national guideline …

Carbon Monoxide Poisoning: From Microbes to Therapeutics

MR Dent, JJ Rose, J Tejero… - Annual review of …, 2024 - annualreviews.org
Carbon monoxide (CO) poisoning leads to 50,000–100,000 emergency room visits and
1,500–2,000 deaths each year in the United States alone. Even with treatment, survivors …

Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response

Z Yuan, LK De La Cruz, X Yang, B Wang, Q Ma - Pharmacological Reviews, 2022 - Elsevier
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication

Q Mao, AT Kawaguchi, S Mizobata, R Motterlini… - Communications …, 2021 - nature.com
Carbon monoxide (CO) is a gaseous molecule known as the silent killer. It is widely believed
that an increase in blood carboxyhemoglobin (CO-Hb) is the best biomarker to define CO …

[HTML][HTML] Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport

A Keppner, D Maric, M Correia, TW Koay, IMC Orlando… - Redox biology, 2020 - Elsevier
Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose
structures and sequences were determined over 50 years ago. In the subsequent …

“CO in a pill”: Towards oral delivery of carbon monoxide for therapeutic applications

X Yang, W Lu, M Wang, C Tan, B Wang - Journal of Controlled Release, 2021 - Elsevier
Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …

'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects

HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …

A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning

Q Mao, X Zhao, A Kiriyama, S Negi… - Proceedings of the …, 2023 - National Acad Sciences
Simultaneous poisoning by carbon monoxide (CO) and hydrogen cyanide is the major
cause of mortality in fire gas accidents. Here, we report on the invention of an injectable …

The role of globins in cardiovascular physiology

TCS Keller 4th, C Lechauve, AS Keller… - Physiological …, 2022 - journals.physiology.org
Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial
cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are …