Mechanical ventilation has been used to support acutely ill patients for several decades. But
clinicians are aware that, despite the life-saving potential of this assistance, it has several …

Positive end-expiratory pressure (PEEP) has been used during mechanical ventilation since
the first description of acute respiratory distress syndrome (ARDS). In the subsequent …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

Objective: To provide an update to the original Surviving Sepsis Campaign clinical
management guidelines,“Surviving Sepsis Campaign Guidelines for Management of Severe …

Background In patients with the acute respiratory distress syndrome, massive alveolar
collapse and cyclic lung reopening and overdistention during mechanical ventilation may …

ContextThe optimal duration of antimicrobial treatment for ventilator-associated pneumonia
(VAP) is unknown. Shortening the length of treatment may help to contain the emergence of …

Sepsis is an infection-induced syndrome defined as the presence of two or more of the
following features of systemic inflammation: fever or hypothermia, leukocytosis or …

The objective of this study was to create a 5-year survivorship model to identify key clinical
features of cystic fibrosis. Such a model could help researchers and clinicians to evaluate …