Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Abstract l-Arginine is an essential amino acid for birds and young mammals, and it is a
conditionally essential amino acid for adult mammals, as it is important in situations in which …

Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and
stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which …

Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive
tumor microenvironment. Myeloid cell expression of arginase 1 (ARG1) promotes a protumor …

Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of
myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer …

Emerging evidence indicates that the Achilles' heel of cancer immunotherapies is often the
complex interplay of tumor‐derived factors and deviant host properties, which involve a wide …

The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …

Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …

The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an
important determinant of the inflammatory response of murine macrophages and dendritic …