Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D
remains unclear. Here, we integratively profiled gut microbial functional and metabolic …

Summary Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the
destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In …

Macrophages are a heterogeneous group of cells that are capable of carrying out distinct
functions in different tissues, as well as in different locations within a given tissue. Some of …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Metabolic derangement with poor glycemic control accompanying overweight and obesity is
associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which …

Unlike other cells in the body, immune cells have to be able to enter and adapt to life within
diverse tissues. Immune cells develop within dedicated immune system organs, such as the …

Objective—Wound monocyte-derived macrophage plasticity controls the initiation and
resolution of inflammation that is critical for proper healing, however, in diabetes mellitus, the …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …