Current insights in cutaneous lupus erythematosus immunopathogenesis

CJ Garelli, MA Refat, PP Nanaware… - Frontiers in …, 2020 - frontiersin.org
Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin
diseases with shared histological features of interface dermatitis and autoantibodies …

The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

W Qiu, T Yu, GM Deng - Frontiers in Immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE), often known simply as lupus, is a severe chronic
autoimmune disease that is characterized by multi-organ and tissue damage and high levels …

Molecular profiling of cutaneous lupus lesions identifies subgroups distinct from clinical phenotypes

CC Berthier, LC Tsoi, TJ Reed, JN Stannard… - Journal of clinical …, 2019 - mdpi.com
Cutaneous lupus erythematosus (CLE) is a common manifestation of systemic lupus
erythematosus (SLE), and CLE can also develop without systemic involvement. CLE can be …

[HTML][HTML] Neutrophils as drivers of immune dysregulation in autoimmune diseases with skin manifestations

S Nakabo, J Romo-Tena, MJ Kaplan - Journal of Investigative Dermatology, 2022 - Elsevier
Dysregulation in the phenotype and function of neutrophils may play important roles in the
initiation and perpetuation of autoimmune responses, including conditions affecting the skin …

Amelioration of lupus serum-induced skin inflammation in CD64-deficient mice

L Jiang, X Han, W Qiu, T Yu, R Feng, X Wang… - Frontiers in …, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder
characterized by high autoantibodies levels and multiorgan tissue damage. The current …

[HTML][HTML] Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking …

JR Weng, TH Huang, ZC Lin, A Alalaiwe… - Biomedicine & …, 2019 - Elsevier
Abstract [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (CIM) has been used
as a bioactive agent for inhibiting tumor growth and angiogenesis via mitogen-activated …

Leptin: an unappreciated key player in SLE

Q Yuan, H Chen, X Li, J Wei - Clinical Rheumatology, 2020 - Springer
Leptin is the forerunner of the adipokine superfamily and plays a key role in regulating
energy expenditure and neuroendocrine function. Researches into leptin put emphasize not …

Animal models of studying the pathogenesis of multi-organ tissue damage in lupus

X Wang, GM Deng - Clinical Immunology, 2024 - Elsevier
Moderate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive
autoantibody deposition and persistent autoinflammation. As the existing animal models are …

Immunoglobulin G inhibits glucocorticoid-induced osteoporosis through occupation of FcγRI

L Jiang, W Qiu, X Wang, X Duan, X Han, T Yu, S Wen… - Iscience, 2023 - cell.com
Glucocorticoid-induced osteoporosis (GIOP) is a severe and common complication of long-
term usage of glucocorticoids (GCs) and lacks of efficient therapy. Here, we investigated the …

Recent advances in cutaneous lupus

MP Maz, JWS Martens, A Hannoudi, AL Reddy… - Journal of …, 2022 - Elsevier
Cutaneous lupus erythematosus (CLE) is an inflammatory and autoimmune skin condition
that affects patients with systemic lupus erythematosus (SLE) and exists as an isolated entity …