The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
With human median lifespan extending into the 80s in many developed countries, the
societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes …
societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes …
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously
expressed regulators of RNA processing. To understand the molecular impact of ALS …
expressed regulators of RNA processing. To understand the molecular impact of ALS …
Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of
individuals aged over 60 years. While rodents are widely-used model organisms, which …
individuals aged over 60 years. While rodents are widely-used model organisms, which …
[PDF][PDF] Nrf2, but not β‐catenin, mutation represents an early event in rat hepatocarcinogenesis
P Zavattari, A Perra, S Menegon, MA Kowalik… - …, 2015 - Wiley Online Library
Hepatocellular carcinoma (HCC) develops through a multistage process, but the nature of
the molecular changes associated with the different steps, the very early ones in particular …
the molecular changes associated with the different steps, the very early ones in particular …
[HTML][HTML] Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute
IR Miousse, R Currie, K Datta, H Ellinger-Ziegelbauer… - Toxicology, 2015 - Elsevier
Recent technological advances have led to rapid progress in the characterization of
epigenetic modifications that control gene expression in a generally heritable way, and are …
epigenetic modifications that control gene expression in a generally heritable way, and are …
Derisking drug-induced carcinogenicity for novel therapeutics
JG Moggs, T MacLachlan, HJ Martus, P Bentley - Trends in Cancer, 2016 - cell.com
Assessing the carcinogenic potential of innovative drugs spanning diverse therapeutic
modalities and target biology represents a major challenge during drug development. Novel …
modalities and target biology represents a major challenge during drug development. Novel …
Automated and unbiased discrimination of ALS from control tissue at single cell resolution
Histopathological analysis of tissue sections is invaluable in neurodegeneration research.
However, cell‐to‐cell variation in both the presence and severity of a given phenotype is a …
However, cell‐to‐cell variation in both the presence and severity of a given phenotype is a …
Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop
PIP3 is synthesized by the Class I PI3Ks and regulates complex cell responses, such as
growth and migration. Signals that drive long-term reshaping of cell phenotypes are difficult …
growth and migration. Signals that drive long-term reshaping of cell phenotypes are difficult …
Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion
Liver cancer susceptibility varies amongst humans and between experimental animal
models because of multiple genetic and epigenetic factors. The molecular characterization …
models because of multiple genetic and epigenetic factors. The molecular characterization …
Meta-analysis of transcriptome data detected new potential players in response to dioxin exposure in humans
E Oshchepkova, Y Sizentsova, D Wiebe… - International Journal of …, 2020 - mdpi.com
Dioxins are one of the most potent anthropogenic poisons, causing systemic disorders in
embryonic development and pathologies in adults. The mechanism of dioxin action requires …
embryonic development and pathologies in adults. The mechanism of dioxin action requires …