New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?

M Shreberk‐Shaked, M Oren - Molecular oncology, 2019 - Wiley Online Library
Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ),
the main effectors of the Hippo pathway, are emerging as important players in cancer …

The power of super-resolution microscopy in modern biomedical science

N Sun, Y Jia, S Bai, Q Li, L Dai, J Li - Advances in Colloid and Interface …, 2023 - Elsevier
Super-resolution microscopy (SRM) technology that breaks the diffraction limit has
revolutionized the field of cell biology since its appearance, which enables researchers to …

Competence for neural crest induction is controlled by hydrostatic pressure through Yap

DN Alasaadi, L Alvizi, J Hartmann, N Stillman… - Nature Cell …, 2024 - nature.com
Embryonic induction is a key mechanism in development that corresponds to an interaction
between a signalling and a responding tissue, causing a change in the direction of …

Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression

L He, L Yuan, Y Sun, P Wang, H Zhang, X Feng… - Cancer research, 2019 - AACR
The Hippo pathway plays a critical role in cell growth and tumorigenesis. The activity of TEA
domain transcription factor 4 (TEAD4) determines the output of Hippo signaling; however …

Role of the cell cycle in collective cell dynamics

J Li, SK Schnyder, MS Turner, R Yamamoto - Physical Review X, 2021 - APS
Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay
between intercellular forces and biochemical regulation. We develop a simple model of the …

Mechanical force regulation of YAP by F-actin and GPCR revealed by super-resolution imaging

J Gao, L He, L Zhou, Y Jing, F Wang, Y Shi, M Cai… - Nanoscale, 2020 - pubs.rsc.org
The Hippo signaling pathway plays critical roles in many biological processes including
mechanotransduction. The key activator YAP of this pathway is considered as a central …

TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition

T Kärki, EK Rajakylä, A Acheva, S Tojkander - Scientific Reports, 2020 - nature.com
Epithelial integrity is lost upon cancer progression as cancer cells detach from the primary
tumor site and start to invade to the surrounding tissues. Invasive cancers of epithelial origin …

Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

L Wehling, L Keegan, P Fernández-Palanca, R Hassan… - Elife, 2022 - elifesciences.org
The Hippo signaling pathway controls cell proliferation and tissue regeneration via its
transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with …

The hippo pathway orchestrates cytoskeletal organisation during intervertebral disc degeneration

C Zhang, F Wang, Z Xie, L Chen, X Wu - Acta Histochemica, 2021 - Elsevier
Yes-associated protein (YAP) activity responded to physical and mechanical cues such as
extracellular matrix (ECM), cell density and the mechanical regulation of YAP controlled …

What we talk about when we talk about nanoclusters

F Baumgart, AM Arnold, BK Rossboth… - … and applications in …, 2018 - iopscience.iop.org
Superresolution microscopy results have sparked the idea that many membrane proteins
are not randomly distributed across the plasma membrane but are instead arranged in …