Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative
approach to small molecules for the modulation of receptor signaling and subsequent gene …

Allosteric interactions play vital roles in metabolic processes and signal transduction and,
more recently, have become the focus of numerous pharmacological studies because of the …

Many tumours originate from cancer stem cells (CSCs), which is a small population of cells
that display stem cell properties. However, the molecular mechanisms that regulate CSC …

Coactivators are a diverse group of non-DNA binding proteins that induce structural
changes in agonist-bound nuclear receptors (NRs) that are essential for NR-mediated …

Because of their central importance in gene regulation and mediating the actions of many
hormones, the nuclear receptors (NRs) have long been recognized as very important …

The α-helix is the most abundant secondary structural element in proteins and is an
important structural domain for mediating protein–protein and protein–nucleic acid …

Described is a facile helix‐nucleating template based on a tethered aspartic acid at the N‐
terminus [terminal aspartic acid (TD)]. The nucleating effect of the template is subtly …