Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Cardiac fibrosis is a common finding that is associated with the progression of heart failure
(HF) and impacts all chambers of the heart. Despite intense research, the treatment of HF …

Cardiovascular diseases cause more mortality and morbidity worldwide than any other
diseases. Although many intracellular signaling pathways influence cardiac physiology and …

The objective of this study was to determine whether a simple, noninvasive method involving
administration of isoproterenol could be used to produce myocardial injury and cardiac …

The aim of the study was to examine the protective effects and possible mechanism of
gossypin against isoproterenol (ISO)-mediated myocardial damage in vivo and H9c2 cell …

The mammalian heart during its development and in response to physiological or
pathological stimuli undergoes hypertrophic enlargement, a consequence of an increase in …

Continuous contraction–relaxation cycles of the heart require strong and stable connections
of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal …

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, a well-
known Chinese medicine for treating cardiovascular disorders. Cardiomyocyte apoptosis …

Integrins are a family of heterodimeric proteins expressed by cardiac fibroblasts and
cardiomyocytes that provide critical adhesive and signaling functions through their …