Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

Intron retention has long been an exemplar of regulated splicing with case studies of
individual events serving as models that provided key mechanistic insights into the process …

Sequences with the potential to form RNA G-quadruplexes (G4s) are common in
mammalian introns, especially in the proximity of the 5′ splice site (5′ SS). However, the …

Nucleic acids form not only the canonical double helix (duplex) but also the non-canonical
(non-double helix) structures such as triplexes, G-quadruplexes, and i-motifs. The formation …

Cotranscriptional folding of an RNA transcript enables formation of metastable RNA
structures. Thermodynamic and kinetic properties of RNA G-quadruplex formation have …

G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA
G-quadruplexes are highly stable due to stacked planar arrangements connected by short …

Splice-site selection is controlled by secondary structure through sequestration or
approximation of splicing signals in primary transcripts but the exact role of even the …

Insulin is amongst the human genome's most well-studied genes/proteins due to its
connection to metabolic health. Within this article, we review literature and data to build a …

CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its
aberrant expression may contribute to a broad spectrum of renal disorders …

Non‐coding RNAs play important roles in cellular homeostasis and are involved in many
human diseases including cancer. Intermolecular RNA–RNA interactions are the basis for …