Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Twenty years have passed since the dysconnection hypothesis was first proposed (Friston
and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous …

In this article, we review clinical research using the mismatch negativity (MMN), a change-
detection response of the brain elicited even in the absence of attention or behavioural task …

Reduced N-methyl-D-aspartate-receptor (NMDAR) signaling has been associated with
schizophrenia, autism and intellectual disability. NMDAR-hypofunction is thought to …

Sequencing of the rat genome has allowed a better understanding of the rat physiology and
biology, in turn promising to translate into a better understanding of human biology and …

The mismatch negativity (MMN) component of the auditory event-related potential has
become a valuable tool in cognitive neuroscience. Its reduced size in persons with …

Over the last fifteen years it has become established that 22q11. 2 deletion syndrome
(22q11DS) is a true genetic risk factor for schizophrenia. Carriers of deletions in …

Recent reviews and meta-analyses suggest that reducing the duration of untreated
psychosis leads to better symptomatic and functional outcome in patients with psychotic …

Reduced NMDA‐receptor (NMDAR) function has been implicated in the pathophysiology of
neuropsychiatric disease, most strongly in schizophrenia but also recently in autism …