Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

A glowing new era in cancer surgery may be dawning. Using fluorescently labelled markers,
surgical molecular navigation means that tumours and nerves can be displayed in real time …

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …

The Precision Medicine Initiative aims to use advances in basic and clinical research to
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …

Proteolytic enzymes are key signaling molecules in both normal physiological processes
and various diseases. After synthesis, protease activity is tightly controlled. Consequently …

In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

When innate immune cells such as macrophages are challenged with environmental
stresses or infection by pathogens, they trigger the rapid assembly of multi-protein …

Breast cancer development largely depends upon the essential contributions from the tumor
microenvironment, where several inflammatory cell populations (eg macrophages) …

Chemical probes are critical tools for elucidating the biological functions of proteins and can
lead to new medicines for treating disease. The pharmacological validation of protein …