The pathomechanism, antioxidant biomarkers, and treatment of oxidative stress-related eye diseases

YJ Hsueh, YN Chen, YT Tsao, CM Cheng… - International Journal of …, 2022 - mdpi.com
Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …

Tacrolimus loaded cationic liposomes for dry eye treatment

X Chen, J Wu, X Lin, X Wu, X Yu, B Wang… - Frontiers in …, 2022 - frontiersin.org
Eye drops are ophthalmic formulations routinely used to treat dry eye. However, the low
ocular bioavailability is an obvious drawback of eye drops owing to short ocular retention …

Cell therapy in the cornea: the emerging role of microenvironment

G Suanno, VG Genna, E Maurizi, AA Dieh… - Progress in Retinal and …, 2024 - Elsevier
The cornea is an ideal testing field for cell therapies. Its highly ordered structure, where
specific cell populations are sequestered in different layers, together with its accessibility …

Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease

SM Navabi, D Elieh-Ali-Komi, D Afshari… - Nutritional …, 2024 - Taylor & Francis
ABSTRACT Background Brain tissue in Alzheimer's patients is exposed to oxidative stress.
Silymarin is an adjunct drug that has anti-inflammatory and antioxidant properties. Objective …

Descemet membrane endothelial keratoplasty: analysis of clinical outcomes of patients with 8–10 years follow-up

JM Weller, FE Kruse, T Tourtas - International Ophthalmology, 2022 - Springer
Purpose This study aimed to evaluate the clinical outcomes up to 10 years after Descemet
membrane endothelial keratoplasty (DMEK). Methods In this retrospective, consecutive …

Accelerated corneal endothelial cell loss after phacoemulsification in patients with mildly low endothelial cell density

HC Chen, CW Huang, LK Yeh, FC Hsiao… - Journal of Clinical …, 2021 - mdpi.com
By evaluating preoperative endothelial cell density (ECD), ECD loss after
phacoemulsification can be predicted. In this retrospective cross-sectional study, we …

An assessment of cataract severity based on antioxidant status and ascorbic acid levels in aqueous humor

YT Tsao, WC Wu, KJ Chen, CF Liu, YJ Hsueh… - Antioxidants, 2022 - mdpi.com
Cataract is the leading cause of blindness throughout the world. Currently, the cataract
severity evaluation is based on the subjective LOCS III guideline. To ameliorate the …

Stability of ascorbic acid in human aqueous humor

S Ito, M Nagata, Y Takino, A Ishigami, T Senoo - BMC Research Notes, 2024 - Springer
Objective The stability of ascorbic acid (AA) in the human aqueous humor (AqH) remains
unclear. This study aimed to investigate the stability of AqH AA under varying conditions (27 …

Chlorine-Induced Toxicity on Murine Cornea: Exploring the Potential Therapeutic Role of Antioxidants

S An, K Anwar, M Ashraf, KY Han, AR Djalilian - Cells, 2024 - mdpi.com
Chlorine (Cl2) exposure poses a significant risk to ocular health, with the cornea being
particularly susceptible to its corrosive effects. Antioxidants, known for their ability to …

Hyperglycemia-depleted glutamine contributes to the pathogenesis of diabetic corneal endothelial dysfunction

M Yu, H Chen, C Chen, C Zhao, Q Zhou, L Xie… - Experimental Eye …, 2024 - Elsevier
Diabetic mellitus (DM) causes various complications, including the corneal endothelial
dysfunction that leads to corneal edema and vision loss, especially in the DM patients with …